منابع مشابه
Size of hippocampal pyramidal neurons in schizophrenia.
BACKGROUND Meta-analyses of hippocampal size have indicated that this structure is smaller in schizophrenia. This could reflect a reduction in the size of constituent neurons or a reduced number of neurons. AIMS To measure the size of hippocampal pyramidal neurons in the brains of people with and without schizophrenia. METHOD Pyramidal neuron size in hippocampal subfields was estimated ster...
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We investigated the potential role of different proteases in the death of cultured rat hippocampal pyramidal neurons induced by /3-amyloid(A~3)(25—35). Both A/1(25—35)and staurosporine-induced death of these neurons appeared to involve apoptosis, as indicated using Hoechst 33342 and terminal dUDP nick end labeling staining, whereas NMDA-induced death appeared more complex. Two irreversible inhi...
متن کاملMicrodomains in Hippocampal Neurons
Ca 2 -binding proteins are ubiquitously expressed throughout the CNS and serve as valuable immunohistochemical markers for certain types of neurons. However, the functional role of most Ca 2 -binding proteins has to date remained obscure because their concentration in central neurons is not known. In this study, we investigate the intracellular concentration of the widely expressed Ca 2 -bindin...
متن کاملCulturing Adult Rat Hippocampal Neurons with Long-Interval Changing Media
Background: Primary cultures of embryonic neurons have been used to introduce a model of neurons in physiological and pathological conditions. However, age-related cellular events limit this method as an optimal model in adult neurodegenerative diseases studies. Besides, short-interval changing media in previous cultures decreases the effectiveness of this model. As an example of this matter, w...
متن کاملChannels in Cultured Hippocampal Neurons
As the Ca 2 -sensor for Ca 2 -dependent inactivation, calmodulin (CaM) has been proposed, but never definitively demonstrated, to be a constitutive CaV1.2 Ca 2 channel subunit. Here we show that CaM is associated with the CaV1.2 pore-forming 1C subunit in brain in a Ca 2 -independent manner. Within its CaM binding pocket, 1C has been proposed to contain a membrane targeting domain. Because ion ...
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ژورنال
عنوان ژورنال: Journal of Neural Transmission
سال: 2002
ISSN: 0300-9564,1435-1463
DOI: 10.1007/s007020200073